PARP3 Polyclonal Antibody

Reddot Biotech

PARP3 Polyclonal Antibody

5

2 mg/ml

PARP3

poly(ADP-ribose) polymerase family member 3

ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3; ADP-ribosyltransferase diphtheria toxin-like 3; ADPRT3; ADPRT-3; ADPRTL2; ADPRTL3; ARTD3; DNA ADP-ribosyltransferase PARP3; IRT1; NAD(+) ADP-ribosyltransferase 3; NAD+ ADP-ribosyltransferase 3; PADPRT-3; poly [ADP-ribose] polymerase 3; poly(ADP-ribose) synthetase-3; poly[ADP-ribose] synthase 3; poly[ADP-ribose] synthetase 3; protein mono-ADP-ribosyltransferase PARP3

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

-20°C

12352203