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ProductsBack/PARPYnD [2561483-27-8]
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PARPYnD [2561483-27-8]

Research Use Only
T41176
TargetMol Chemicals
Molecular Weight613.67
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PARPYnD [2561483-27-8]
  • Delivery Days Customer
    44
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PARPYnD
  • Molecular Formula
    C34H31N9O3
  • Molecular Weight
    613.67
  • Scientific Description
    PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.
  • Shelf life instruction
    3 years
  • SMILES
    C(CC(NC=1C=C(C#N)C(=NC1)N2CCN(C(=O)C3=CC(CC=4C=5C(C(=O)NN4)=CC=CC5)=CC=C3)CC2)=O)C6(CCC#C)N=N6
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Howard et al (2020) Structure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors. ACS Chem.Biol. 15 325 PMID: 32017532
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