PARPYnD

MedChem Express

PARPYnD

14

Research Use Only

C34H31N9O3

613.67

PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells[1].

N#CC1=CC(NC(CCC2(CCC#C)N=N2)=O)=CN=C1N3CCN(CC3)C(C4=CC=CC(CC5=NNC(C6=C5C=CC=C6)=O)=C4)=O

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