Parthenolide [20554-84-1]
P0270
Estimated Purity≥98%
Product group Chemicals
Overview
- SupplierLKT Laboratories
- Product NameParthenolide [20554-84-1]
- Delivery Days Customer7
- CertificationResearch Use Only
- Estimated Purity≥98%
- FormatDMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.
- Scientific DescriptionSesquiterpene lactone found in Tanacetum; TRPA1 partial agonist, NLRP3 and caspase 1 inhibitor.
- Storage Instruction4°C
- UNSPSC12352200
References
- Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33(1):3. PMID: 24387758. Materazzi S, Benemei S, Fusi C, et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain. 2013 Dec;154(12):2750-8. PMID: 23933184. D'Anneo A, Carlisi D, Lauricella M, et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013 Oct 31;4:e891. PMID: 24176849. Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-802. PMID: 20093358. https://en.wikipedia.org/wiki/Parthenolide