PC1 antibody

GeneTex

PC1 antibody

9

WB: 0.4 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Pcsk1

proprotein convertase subtilisin/kexin type 1

furin homolog; Nec; Nec-; Nec1; Nec-1; neuroendocrine convertase 1; PC; PC1; PC3; Php; Phpp-1; prohormone convertase 1; prohormone convertase 1/3; propeptide-processing protease; SP; SPC3

Rabbit

IgG

Neuroendocrine convertase 1

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Mouse

-20°C or -80°C,2°C to 8°C

12352203