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WB analysis of 25 ug of mouse cerebellum cell lysates using GTX23533 PC2 antibody. Dilution : 1:500
WB analysis of 25 ug of mouse cerebellum cell lysates using GTX23533 PC2 antibody. Dilution : 1:500
WB analysis of 25 ug of mouse cerebellum cell lysates using GTX23533 PC2 antibody. Dilution : 1:500

PC2 antibody

GTX23533
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetPcsk2
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Overview

  • Supplier
    GeneTex
  • Product Name
    PC2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 2 microg/ml. ICC/IF: 1:20-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID18549
  • Target name
    Pcsk2
  • Target description
    proprotein convertase subtilisin/kexin type 2
  • Target synonyms
    6330411F23Rik; AI839700; KEX2-like endoprotease 2; Nec; Nec-; NEC 2; Nec2; Nec-2; neuroendocrine convertase 2; PC; PC2; Php; Phpp-2; prohormone convertase 2; proprotein convertase 2; SP; SPC2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP21661
  • Protein Name
    Neuroendocrine convertase 2
  • Scientific Description
    The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimers disease. Barranco N et al., 2021 Sep 26, Transl Neurodegener
    Read more
  • PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Knoch KP et al., 2014 Aug, Mol Metab
    Read more
  • Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hatanaka M et al., 2011 Apr 1, Hum Mol Genet
    Read more