PCI-29732

AbMole BioScience

PCI-29732

9

330786-25-9

Chemical

Research Use Only

C22H21N5O

371.44

PCI-29732 is a potent, reversible BTK inhibitor with Kiapp values of 8.2, 4.6, and 2.5 nM for BTK, Lck, and Lyn, respectively, and has only modest inhibitory activity against Itk, another Tec family kinase. In addition, PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP binding site of ABCG2.

NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CC=C(OC5=CC=CC=C5)C=C4

12352200