PCP4 Polyclonal Antibody

Reddot Biotech

PCP4 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PCP4

Purkinje cell protein 4

brain specific polypeptide PEP19; brain-specific antigen PCP-4; brain-specific polypeptide PEP-19; calmodulin regulator protein PCP4; PEP-19

Rabbit

IgG

PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer,Aeos disease and Huntingtons disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Human, Mouse, Rat

-20°C

12352203