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ProductsBack/PCSK9 Recombinant Monoclonal Antibody
Western Blot Positive WB detected in: PC-3 whole cell lysate All lanes: PCSK9 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 75, 21 kDa Observed band size: 60, 75 kDa
Western Blot Positive WB detected in: PC-3 whole cell lysate All lanes: PCSK9 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 75, 21 kDa Observed band size: 60, 75 kDa
Western Blot Positive WB detected in: PC-3 whole cell lysate All lanes: PCSK9 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 75, 21 kDa Observed band size: 60, 75 kDa

PCSK9 Recombinant Monoclonal Antibody

CSB-RA259644A0HU
Cusabio
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPCSK9
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Overview

  • Supplier
    Cusabio
  • Product Name
    PCSK9 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    7F2
  • Conjugate
    Unconjugated
  • Gene ID255738
  • Target name
    PCSK9
  • Target description
    proprotein convertase subtilisin/kexin type 9
  • Target synonyms
    convertase subtilisin/kexin type 9 preproprotein; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC1; NARC-1; neural apoptosis regulated convertase 1; PC9; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9
  • Isotype
    IgG
  • Protein IDQ8NBP7
  • Protein Name
    Proprotein convertase subtilisin/kexin type 9
  • Scientific Description
    Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203