PD-1-IN-25 [2413100-40-8]

TargetMol Chemicals

PD-1-IN-25 [2413100-40-8]

16

Research Use Only

C37H35ClF2N2O9

725.13

PD-1-IN-25 (compound 43) serves as a powerful inhibitor of the PD-1/PD-L1 interaction, boasting an impressive IC50 of 10.2 nM, as measured in the HTRF assay. By impeding PD-1/PD-L1 cellular signaling, PD-1-IN-25 facilitates the activation of CD8+ T cells. Furthermore, it has been shown to delay tumor growth [1].

CC1=C(C=2C=C3C(=CC2)OCCO3)C=CC=C1C(OC4=CC(OCC5=CC(C#N)=CC=C5)=C(CN[C@H]6[C@@H](O)[C@H](O)[C@@H](CO)OC6O)C=C4Cl)(F)F

-20°C

51202000