PD1, Mouse(RMP1-14), CF568 conjugate, 0.1mg/mL [26628-22-8]

Biotium

PD1, Mouse(RMP1-14), CF568 conjugate, 0.1mg/mL

9

Functional Assay, Flow Cytometry

Research Use Only

Monoclonal

RMP1-14

0.1 mg/ml

Other Conjugate

P2RX3

purinergic receptor P2X 3

ATP receptor; P2X purinoceptor 3; P2X receptor, subunit 3; P2X3; purinergic receptor P2X, ligand gated ion channel, 3; purinergic receptor P2X3; purinoceptor P2X3

Rat

IgG2a

Programmed cell death protein 1

PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Mouse, Rat

2°C to 8°C

12352203