PDCD1 Antibody / PD-1 / PD1

Biorbyt

PDCD1 Antibody / PD-1 / PD1

16

Optimal dilution of the antibody should be determined by the researcher.

ELISA (order BSA/azide-free format for coating),Neutralization Studies (order BSA/azide-free format),Flow cytometry: 1-2ug/million cells in 0.1ml,Immunofluorescence: 0.5-1ug/ml ELISA, FACS, IF, NeA

Research Use Only

Monoclonal

RMP1-14

Unconjugated

Pdcd1

programmed cell death 1

Ly101; mPD-1; PD-; PD-1; Pdc; Pdc1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1

Rat

IgG2a

Programmed cell death protein 1

PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).

Mouse

-20°C,2°C to 8°C

12352203