PDE1-IN-9

MedChem Express

PDE1-IN-9

5

Research Use Only

PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 ( PDE1 ), that inhibits PDE1C with an IC 50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1beta, IL-6, TNF-alpha and iNOS, inhibits the production of nitric oxide ( NO ) and reactive oxygen species ( ROS ). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes [1] .

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