PDE10A-HEK293 Recombinant Cell line

BPS Bioscience

PDE10A-HEK293 Recombinant Cell line

7

Research Use Only

PDE10A

phosphodiesterase 10A

ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3',5' cAMP/cGMP phosphodiesterase, dJ416F21.1 (phosphodiesterase 10A), phosphodiesterase 10A1 (PDE10A1), phosphodiesterase 10A7 (PDE10A7)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Recombinant HEK293 cell line expressing human PDE10A2 (phosphodiesterase 10A, accession number NM_006661). N-terminal His-tagged human PDE10A2 has been stably expressed in a human embryonic kidney (HEK293) cell line. PDE10A2 expression was confirmed by Western blotting. The function of PDE10A2 was confirmed by cAMP detection assay. Forskolin is commonly used to raise levels of intracellular cyclic AMP (cAMP). When HEK293 cells are activated by forskolin, cAMP levels are upregulated in parental cells, whereas cells overexpressing PDE10A show reduction in cAMP accumulation. Inhibition of PDE10A activity restores cAMP levels.

Liquid Nitrogen

41116106

Human