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ProductsBack/PDGF Receptor beta antibody [PR7212]

PDGF Receptor beta antibody [PR7212]

GTX42416
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHamster, Human, Monkey, Primate
TargetPDGFRB
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Overview

  • Supplier
    GeneTex
  • Product Name
    PDGF Receptor beta antibody [PR7212]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is specific for human PDGF receptor beta protein, and it does not cross react with human PDGF receptor alpha protein.
  • Application Supplier Note
    FACS: 25microg/ml. IP: 25microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    PR7212
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5159
  • Target name
    PDGFRB
  • Target description
    platelet derived growth factor receptor beta
  • Target synonyms
    Activated tyrosine kinase PDGFRB; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; IBGC4; IMF1; JTK12; KOGS; NDEL1-PDGFRB; PDGFR; PDGFR1; PDGFR-1; PDGF-R-beta; PDGFR-beta; PENTT; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP09619
  • Protein Name
    Platelet-derived growth factor receptor beta
  • Scientific Description
    The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
  • Reactivity
    Hamster, Human, Monkey, Primate
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. Gilbertson DG et al., 2001 Jul 20, J Biol Chem
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  • Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study. Wang J et al., 1994 Jan 15, Cancer Res
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  • Platelet-derived growth factor receptor immunoreactivity in mesothelioma and nonneoplastic mesothelial cells in serous effusions. Ascoli V et al., 1995 Jul-Aug, Acta Cytol
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  • Two classes of PDGF receptor recognize different isoforms of PDGF. Hart CE et al., 1988 Jun 10, Science
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  • Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. Seifert RA et al., 1989 May 25, J Biol Chem
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  • Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody. Hart CE et al., 1987 Aug 5, J Biol Chem
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  • In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors. Franklin WA et al., 1990 Oct 1, Cancer Res
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  • Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis. Krane JF et al., 1991 Jun, J Invest Dermatol
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  • Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors. Palman C et al., 1992 Jan, Lab Invest
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