PDK4 Antibody, HRP conjugated
CSB-PA614983LB01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetPDK4
Overview
- SupplierCusabio
- Product NamePDK4 Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- Gene ID5166
- Target namePDK4
- Target descriptionpyruvate dehydrogenase kinase 4
- Target synonyms[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
- HostRabbit
- IsotypeIgG
- Protein IDQ16654
- Protein Name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
- Scientific DescriptionKinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203