PDXP Protein, Mouse, Recombinant (His & SUMO)

TargetMol Chemicals

PDXP Protein, Mouse, Recombinant (His & SUMO)

16

Research Use Only

47.5 kDa (predicted)

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5-phosphate (PNP) and pyridoxamine 5-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates Ser-3 in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine.

-20°C

12352200