PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody

Reddot Biotech

PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

G043H7

Double Conjugated

CCR7

C-C motif chemokine receptor 7

BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; CC-CKR-7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; CMKBR7; EBI1; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

Mouse

IgG2a

CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Na?ve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details

Human

2°C to 8°C

12352203