PE/Cyanine7 Anti-Human CD196/CCR6 Antibody

Reddot Biotech

PE/Cyanine7 Anti-Human CD196/CCR6 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

G034E3

Double Conjugated

CCR6

C-C motif chemokine receptor 6

BN-1; C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKRL3; CKR-L3; CMKBR6; DCR2; DRY6; G protein-coupled receptor 29; GPR29; GPRCY4; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22

Mouse

IgG2b

CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the beta defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Human

2°C to 8°C

12352203