PE/Cyanine7 Anti-Mouse CD200 Antibody

Reddot Biotech

PE/Cyanine7 Anti-Mouse CD200 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

OX-90

0.2 mg/ml

Double Conjugated

CD200

CD200 molecule

antigen identified by monoclonal antibody MRC OX-2; CD200 antigen; MOX1; MOX2; MRC; OX-2; OX-2 membrane glycoprotein

Rat

IgG2a

CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells,?B cells,?and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages.?CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues.?CD200 is the ligand for CD200 receptor (CD200R).?The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity.?Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

Mouse

2°C to 8°C

12352203