PE/Cyanine7 Anti-Mouse CD51 Antibody

Reddot Biotech

PE/Cyanine7 Anti-Mouse CD51 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

RMV-7

Double Conjugated

Itgav

integrin alpha V

1110004F14Rik; 2610028E01Rik; alpha v integrin; CD51; D430040G12Rik; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha

Rat

IgG1

CD51 is a 140 kD protein, also known as Oe+/-V?integrin, vitronectin receptor, and integrin Oe+/-V. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins beta1, beta3, beta5?or beta6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The Oe+/-vintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Mouse

2°C to 8°C

12352203