Chemical Structure
Chemical Structure
Pelitinib [257933-82-7]
SYN-1141
CAS Number257933-82-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight467.9
Overview
- SupplierSYNkinase
- Product NamePelitinib [257933-82-7]
- Delivery Days Customer10
- CAS Number257933-82-7
- CertificationResearch Use Only
- Estimated Purity>95%
- Hazard InformationWarning
- Molecular FormulaC24H23ClFN5O2
- Molecular Weight467.9
- Scientific DescriptionChemical. CAS: 257933-82-7. Formula: C24H23ClFN5O2. MW: 467.9. Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway. - Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200