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ProductsBack/Perifosine [157716-52-4]

Perifosine [157716-52-4]

Research Use Only
P1969
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 228,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Perifosine [157716-52-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in water (45 mg/mL). Soluble in ethanol (45 mg/mL). Soluble in chloroform, methanol.
  • Scientific Description
    Alkylphospholipid analog; Akt inhibitor.; KRX-0401; 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate; KRX0401; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Gradziel CS, Wang Y, Stec B, et al. Cytotoxic amphiphiles and phosphoinositides bind to two discrete sites on the Akt1 PH domain. Biochemistry. 2014 Jan 28;53(3):462-72. PMID: 24383815. Shen J, Liang L, Wang C. Perifosine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alfa production via regulation multiple signaling pathways: new implication for Kawasaki disease (KD) treatment. Biochem Biophys Res Commun. 2013 Jul 26;437(2):250-5. PMID: 23806687. Richardson PG, Eng C, Kolesar J, et al. Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity. Expert Opin Drug Metab Toxicol. 2012 May;8(5):623-33. PMID: 22512706. Fei HR, Chen G, Wang JM, et al. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. 2010 Oct;62(5):449-60. PMID: 20842425.