PERK-IN-5 [2616821-91-9]

TargetMol Chemicals

PERK-IN-5 [2616821-91-9]

10

Chemical

Research Use Only

PERK-IN-5

C25H26F2N4O3

468.5

PERK-IN-5 is a highly selective, potent, orally active inhibitor of protein kinase R-like endoplasmic reticulum (ER) kinase (PERK), displaying inhibition with IC50 values of 2 nM for PERK and 9 nM for p-eIF2alpha. PERK-IN-5 significantly inhibited tumor growth in the 786-O renal cell carcinoma xenograft tumor model.

3 years

CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)C

-20°C

51202000