PF-06273340 [1402438-74-7]

TargetMol Chemicals

PF-06273340 [1402438-74-7]

10

1402438-74-7

Chemical

Research Use Only

PF-06273340

98%

C23H22ClN7O3

479.92

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 x 10 6 cm s 1).

3 years

C(=O)(C=1C=2C(N(C(CO)(C)C)C1)=NC(N)=NC2)C=3C=C(NC(CC4=CC=C(Cl)C=N4)=O)C=NC3

-20°C

12352200