PF-06372865

MedChem Express

PF-06372865 [1614245-70-3]

10

1614245-70-3

Research Use Only

99.29

C22H21FN4O3S

440.49

PF-06372865 is an orally active, alpha2/alpha3/alpha5 subtype-selective GABA A positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABA A receptors containing alpha1/alpha2/alpha3/alpha5 subunits ( K i s of 2.9 nM, 21 nM, 134 nM for alpha2, alpha1 PAM, alpha2 PAM, respectively), with low affinity for alpha4/alpha6 subunits. PF-06372865 can across the blood-brain barrier (BBB). PF-06372865 has anxiolytic activity and has the potential for epilepsy [1] .

CCN1C2=NN=CC(C(C=C3)=CC(C(C=CC([S](CC)(=O)=O)=C4)=C4OC)=C3F)=C2N=C1

2°C to 8°C

12352200