PF-543 (hydrochloride)
HY-15425B
CAS Number1706522-79-3
Product group Chemicals
Molecular Weight502.07
Overview
- SupplierMedChem Express
- Product NamePF-543 (hydrochloride) [1706522-79-3]
- Delivery Days Customer10
- CAS Number1706522-79-3
- CertificationResearch Use Only
- Molecular FormulaC27H32ClNO4S
- Molecular Weight502.07
- Scientific DescriptionPF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy[1][2][3].
- SMILES[H]Cl.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O
- UNSPSC12352200
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Product group Chemicals
CAS Number1706522-79-3
Estimated Purity99.92%
Molecular Weight502.1
- SizePrice
Product group Chemicals
PF-543 hydrochlorideORB1298593
CAS Number1706522-79-3
Estimated Purity99.92%
Molecular Weight502.1
- SizePrice