PF-915275 [857290-04-1]

MedChem Express

PF-915275 [857290-04-1]

10

857290-04-1

Research Use Only

99.74

C18H14N4O2S

350.39

PF-915275 is a potent, selective and orally active human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively[1][2][3].

N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1

-20°C,2°C to 8°C

12352200