Immunohistochemical analysis of paraffin-embedded human brain tissue, using ALK (Phospho-Tyr1096) antibody (left)or the same antibody preincubated with blocking peptide (right).
Immunohistochemical analysis of paraffin-embedded human brain tissue, using ALK (Phospho-Tyr1096) antibody (left)or the same antibody preincubated with blocking peptide (right).
Phospho-ALK (Tyr1096) Antibody
CSB-PA116393
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetALK
Overview
- SupplierCusabio
- Product NamePhospho-ALK (Tyr1096) Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID238
- Target nameALK
- Target descriptionALK receptor tyrosine kinase
- Target synonymsALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3
- HostRabbit
- IsotypeIgG
- Protein IDQ9UM73
- Protein NameALK tyrosine kinase receptor
- Scientific DescriptionThe 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3 half of ALK, derived from chromosome 2, is fused to the 5 portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. Morris S.W., Oncogene 14:2175-2188(1997). Morris S.W., Oncogene 15:2883-2883(1997). Iwahara T., Oncogene 14:439-449(1997).
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C
- UNSPSC12352203