Western Blot analysis of various cells using Phospho-AMPK alpha1/2 (Thr183/172) Polyclonal Antibody at dilution of 1:500
Western Blot analysis of various cells using Phospho-AMPK alpha1/2 (Thr183/172) Polyclonal Antibody at dilution of 1:500
Phospho-AMPKalpha1/2 (T183/172) Polyclonal Antibody
E-AB-21121
Protein IDQ13131
Product group Proteins / Signaling Molecules
Overview
- SupplierElabscience
- Product NamePhospho-AMPKalpha1/2 (T183/172) Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierWB,IHC,ELISA
- CertificationResearch Use Only
- Concentration1 mg/ml
- Protein IDQ13131
- Protein Name5'-AMP-activated protein kinase catalytic subunit alpha-1
- Scientific DescriptionAMPK (for 5-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic alpha subunit and regulatory beta and gamma subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation.Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively.
- UNSPSC12352202