Western blot analysis of extracts from HT29 cells treated with CalyculinA using Phospho-FANCD2 (Ser222) antibody.The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HT29 cells treated with CalyculinA using Phospho-FANCD2 (Ser222) antibody.The lane on the right is treated with the antigen-specific peptide.
Phospho-FANCD2 (Ser222) Antibody
CSB-PA234235
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetFANCD2
Overview
- SupplierCusabio
- Product NamePhospho-FANCD2 (Ser222) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID2177
- Target nameFANCD2
- Target descriptionFA complementation group D2
- Target synonymsFA4; FACD; FAD; FAD2; FA-D2; FANCD; Fanconi anemia complementation group D2; Fanconi anemia group D2 protein
- HostRabbit
- IsotypeIgG
- Protein IDQ9BXW9
- Protein NameFanconi anemia group D2 protein
- Scientific DescriptionRequired for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Ho GP, Margossian S, Taniguchi T, DAndrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 .
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203