Western blot analysis of extracts from COS7 cells (Lane 2), using FOS (Phospho-Thr232) Antibody. The lane on the left is treated with antigen-specific peptide.
Phospho-FOS (Thr232) Antibody
CSB-PA595307
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetFOS
Overview
- SupplierCusabio
- Product NamePhospho-FOS (Thr232) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID2353
- Target nameFOS
- Target descriptionFos proto-oncogene, AP-1 transcription factor subunit
- Target synonymsactivator protein 1; AP-1; cellular oncogene c-fos; C-FOS; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; p55; proto-oncogene c-Fos
- HostRabbit
- IsotypeIgG
- Protein IDP01100
- Protein NameProto-oncogene c-Fos
- Scientific DescriptionNuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. van Straaten F. Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983). Hai T., Genes Dev. 3:2083-2090(1989). Heilig R., Nature 421:601-607(2003).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203