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Western blot analysis of extracts from Mouse brain tissue using Fyn (Phospho-Tyr530) Antibody.The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of extracts from Mouse brain tissue using Fyn (Phospho-Tyr530) Antibody.The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of extracts from Mouse brain tissue using Fyn (Phospho-Tyr530) Antibody.The lane on the left is treated with the antigen-specific peptide.

Phospho-FYN (Tyr530) Antibody

CSB-PA112548
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetFYN
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-FYN (Tyr530) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID2534
  • Target name
    FYN
  • Target description
    FYN proto-oncogene, Src family tyrosine kinase
  • Target synonyms
    c-syn protooncogene; FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator; p59-FYN; proto-oncogene c-Fyn; proto-oncogene Syn; SLK; src/yes-related novel; src-like kinase; SYN; tyrosine kinase p59fyn(T); tyrosine-protein kinase Fyn
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP06241
  • Protein Name
    Tyrosine-protein kinase Fyn
  • Scientific Description
    Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203