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Western blot analysis of extracts from HepG2 cells using HDAC1 (Phospho-Ser421) Antibody.The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of extracts from HepG2 cells using HDAC1 (Phospho-Ser421) Antibody.The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of extracts from HepG2 cells using HDAC1 (Phospho-Ser421) Antibody.The lane on the left is treated with the antigen-specific peptide.

Phospho-HDAC1 (Ser421) Antibody

CSB-PA599472
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHDAC1
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-HDAC1 (Ser421) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID3065
  • Target name
    HDAC1
  • Target description
    histone deacetylase 1
  • Target synonyms
    GON-10; HD1; histone deacetylase 1; KDAC1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13547
  • Protein Name
    Histone deacetylase 1
  • Scientific Description
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203