Western blot analysis of extracts from JK cells (Lane 2), using MuSK (Phospho-Tyr755) Antibody. The lane on the left is treated with antigen-specific peptide.
Western blot analysis of extracts from JK cells (Lane 2), using MuSK (Phospho-Tyr755) Antibody. The lane on the left is treated with antigen-specific peptide.
Phospho-MUSK (Tyr755) Antibody
CSB-PA204567
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMUSK
Overview
- SupplierCusabio
- Product NamePhospho-MUSK (Tyr755) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4593
- Target nameMUSK
- Target descriptionmuscle associated receptor tyrosine kinase
- Target synonymsCMS9; FADS; FADS1; muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor
- HostRabbit
- IsotypeIgG
- Protein IDO15146
- Protein NameMuscle, skeletal receptor tyrosine-protein kinase
- Scientific DescriptionReceptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. Valenzuela D.M., Neuron 15:573-584(1995). Humphray S.J., Nature 429:369-374(2004). Bergamin E., Mol. Cell 39:100-109(2010).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203