Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody

Reddot Biotech

Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody

5

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

AGM7; GRB1; IMD36; p85; p85-ALPHA; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3K regulatory subunit alpha; PI3-kinase subunit p85-alpha; ptdIns-3-kinase regulatory subunit alpha

Rabbit

IgG

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Human, Monkey, Mouse, Rat

-20°C

12352203