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ProductsBack/Phospho-PRKCB (Thr641) Antibody
Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCbeta (phospho-Thr641) antibody.
Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCbeta (phospho-Thr641) antibody.
Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCbeta (phospho-Thr641) antibody.

Phospho-PRKCB (Thr641) Antibody

CSB-PA206081
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPRKCB
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-PRKCB (Thr641) Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5579
  • Target name
    PRKCB
  • Target description
    protein kinase C beta
  • Target synonyms
    PKCB; PKC-B; PKCbeta; PKC-beta; PKCI(2); PRKCB1; PRKCB2; protein kinase C beta type; protein kinase C, beta 1 polypeptide
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP05771
  • Protein Name
    Protein kinase C beta type
  • Scientific Description
    Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. Zhang Y, et al. (2006) Mol Cell Biol ; 26: 6748-6761 Castoria G, et al. (2004) Mol Cell Biol ; 24: 7643-7653 Marcil J, et al. (1999) Biochem J ; 337:185-192 Bornancin F, et al. (1996) Curr Biol ; 6:1114-1123.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203