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ProductsBack/Phospho-SHC1 (Tyr349) Antibody
Western blot analysis of extracts from HepG2 cells untreated or treated with EGF using Shc1(Phospho-Tyr349) Antibody.
Western blot analysis of extracts from HepG2 cells untreated or treated with EGF using Shc1(Phospho-Tyr349) Antibody.
Western blot analysis of extracts from HepG2 cells untreated or treated with EGF using Shc1(Phospho-Tyr349) Antibody.

Phospho-SHC1 (Tyr349) Antibody

CSB-PA907557
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse
TargetSHC1
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-SHC1 (Tyr349) Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID6464
  • Target name
    SHC1
  • Target description
    SHC adaptor protein 1
  • Target synonyms
    SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP29353
  • Protein Name
    SHC-transforming protein 1
  • Scientific Description
    Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span Trampont P, et al. (2006) Mol Cell Biol; 26(23): 9035-9044. Patrussi L, et al. (2005) Oncogene; 24(13): 2218-2228 van der Geer P, et al. (1996) Curr Biol ; 6(11): 1435-1444
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203