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Western Blot Positive WB detected in 293 whole cell lysate(treated with Calyculin A or Pervanadate) All lanes Phospho-TP53 antibody at 1.28microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 KDa Observed band size: 53 KDa
Western Blot Positive WB detected in 293 whole cell lysate(treated with Calyculin A or Pervanadate) All lanes Phospho-TP53 antibody at 1.28microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 KDa Observed band size: 53 KDa
Western Blot Positive WB detected in 293 whole cell lysate(treated with Calyculin A or Pervanadate) All lanes Phospho-TP53 antibody at 1.28microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 KDa Observed band size: 53 KDa

Phospho-TP53 (T55) Recombinant Monoclonal Antibody

CSB-RA024077A55PHHU
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetTP53
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-TP53 (T55) Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    3C3
  • Conjugate
    Unconjugated
  • Gene ID7157
  • Target name
    TP53
  • Target description
    tumor protein p53
  • Target synonyms
    antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53
  • Isotype
    IgG
  • Protein IDP04637
  • Protein Name
    Cellular tumor antigen p53
  • Scientific Description
    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203