Phospho-YAP1 (Ser127) Antibody

Cusabio

Phospho-YAP1 (Ser127) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66 Yang S, et al. (2014) Cell Signal 26, 343-51 Sun W, et al. (2014) Mol Biol Rep 41, 947-56

Human, Mouse, Rat

-20°C or -80°C

12352203