PHOX2B Polyclonal Antibody

Reddot Biotech

PHOX2B Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

PHOX2B

paired like homeobox 2B

CCHS; NBLST2; NBPhox; neuroblastoma paired-type homeobox protein; neuroblastoma Phox; paired like homeobox2B; paired mesoderm homeobox 2b; paired mesoderm homeobox protein 2B; PHOX2B homeodomain protein; PMX2B

Rabbit

IgG

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Human, Mouse, Rat

-20°C

12352203