Physalin H
TN4778
CAS Number70241-09-7
Product group Chemicals
Molecular Weight562.99
Overview
- SupplierTargetMol Chemicals
- Product NamePhysalin H
- Delivery Days Customer1001
- CAS Number70241-09-7
- Category SupplierChemical
- Chemical NamePhysalin H
- Molecular FormulaC28H31ClO10
- Molecular Weight562.99
- Scientific DescriptionPhysalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.
- Shelf life instruction3 years
- SMILESC[C@]12[C@]34[C@]5([C@@]6(C)[C@@](CO[C@](O3)(C5=O)[C@]7([C@](CC[C@@]4(O)C(=O)O1)([C@]8(C)[C@@](Cl)([C@H](O)C7)CC=CC8=O)[H])[H])(C(=O)O[C@@H]2C6)[H])[H]
- Storage Instruction-20°
- UNSPSC12352200