PI-540

MedChem Express

PI-540

5

C22H27N5O2S

425.55

PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC 50 s of 10 nM (P110alpha), 3510 nM (P110beta), 410 nM (P110delta), and 33110 nM (P110gamma). PI-540 also inhibits mTOR ( IC 50 : 61 nM) and DNA-PK ( IC 50 : 525 nM) [1] .

OC1=CC=CC(C2=NC(N3CCOCC3)=C(SC(CN4CCN(C)CC4)=C5)C5=N2)=C1

12352200