PIAS1 antibody, PAb
ORB67014
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPIAS1
Overview
- SupplierBiorbyt
- Product NamePIAS1 antibody, PAb
- Delivery Days Customer16
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB:1:1000-1:5000,IP:1:50-1:100,IF:1:100-1:200,IHC:1:100-1:200 ICC, IF, IHC-P, IP, WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID8554
- Target namePIAS1
- Target descriptionprotein inhibitor of activated STAT 1
- Target synonymsAR interacting protein; DDXBP1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; GU/RH-II; gu-binding protein; protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; ZMIZ3
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203