PIAS4 Antibody, HRP conjugated

Cusabio

PIAS4 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

PIAS4

protein inhibitor of activated STAT 4

E3 SUMO-protein ligase PIAS4; Piasg; PIAS-gamma; PIASY; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein gamma; protein inhibitor of activated STAT protein PIASy; RING-type E3 ubiquitin transferase PIAS4; zinc finger, MIZ-type containing 6; ZMIZ6

Rabbit

IgG

E3 SUMO-protein ligase PIAS4

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Human

-20°C or -80°C

12352203