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ProductsBack/Pifithrin-alfa-cyclic Hydrobromide [511296-88-1]

Pifithrin-alfa-cyclic Hydrobromide [511296-88-1]

Research Use Only
P327212
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 335,00
25 mg
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More than 130 suppliers
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Pifithrin-alfa-cyclic Hydrobromide [511296-88-1]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Scientific Description
    p53 inhibitor; Pifithrin-beta hydrobromide
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Komarova EA, Nenanov N, Komarov PG, et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem. 2003 May 2;278(18):15465-15468. PMID: 12637507. Rocha S, Campbell KJ, Roche KC, et al. The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. BMC Mol Biol. 2003 Sep 11;4:9. PMID: 12967348. Kanno S, Kurachi K, Tomizawa A, et al. Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells. Toxicl Lett. 2015 Jan 22, 232(2):393-402. PMID: 25448278. Murphy PJ, Galigniana MD, Morishima Y, et al. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem. 2004 Jul 16;279(29):30195-30201. PMID: 15145929. Zuco V, Zunino F. Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia. 2008 Jun;10(6):587-596. PMID: 18516295.