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ProductsBack/Pifithrin-alpha . HBr [63208-82-2]
Chemical Structure
Chemical Structure
Chemical Structure

Pifithrin-alpha . HBr [63208-82-2]

Research Use Only
AG-CR1-0004
AdipoGen Life Sciences
CAS Number63208-82-2
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight286.4 . 80.9
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Pifithrin-alpha hydrobromide [63208-82-2]
  • Delivery Days Customer
    10
  • CAS Number
    63208-82-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C16H18N2OS . HBr
  • Molecular Weight
    286.4 . 80.9
  • Scientific Description
    Chemical. CAS: 63208-82-2. Formula: C16H18N2OS . HBr. MW: 286.4 . 80.9. p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor. - p53 inhibitor [1, 2]. Reversibly blocks p53-dependent transcriptional activation [2]. Tool to combat side effects of cancer therapy [3]. Apoptosis inhibitor [1, 2, 4].
  • SMILES
    [Br].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999)
  • Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004)
  • Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999)
  • Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002)