PIG3 antibody [AT1C9]

GeneTex

PIG3 antibody [AT1C9]

9

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:3,000.

Western Blot, ELISA

Research Use Only

Monoclonal

AT1C9

1 mg/ml

Unconjugated

TP53I3

tumor protein p53 inducible protein 3

p53-induced gene 3 protein; PIG3; quinone oxidoreductase homolog; quinone oxidoreductase PIG3

Mouse

IgG2a

Quinone oxidoreductase PIG3

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Human

-20°C or -80°C,2°C to 8°C

12352203