PIG3 Protein, Human, Recombinant (His)

TargetMol Chemicals

PIG3 Protein, Human, Recombinant (His)

16

Research Use Only

37.8 kDa (predicted); 37.5 kDa (reducing conditions)

Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3.

-20°C

12352200