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ProductsBack/PIK-75 Hydrochloride [372196-77-5]

PIK-75 Hydrochloride [372196-77-5]

Research Use Only
P3540
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 338,00
25 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    PIK-75 Hydrochloride [372196-77-5]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in DMSO(4mg/mL), DMF; Water Insoluble; Ethanol Insoluble
  • Scientific Description
    p110alfa PI3K inhibitor.; PIK-75 HCl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Buchanan CM, Dickson JM, Lee WJ, et al. Oncogenic mutations of p110alfa isoform of PI 3-kinase upregulate its protein kinase activity. PLoS One. 2013 Aug 1;8(8):e71337. PMID: 23936502. Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, et al. Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic bèta-cells. PLoS One. 2012;7(10):e47381. PMID: 23077605. Smirnova T, Zhou ZN, Flinn RJ, et al. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 2012 Feb 9;31(6):706-15. PMID: 21725367. Dagia NM, Agarwal G, Kamath DV, et al. A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. PMID: 20089935.